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. 2020 Feb 7;10:2168. doi: 10.1038/s41598-020-58901-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Deletion of Asic5 slows the maximum depolarization rate of type II UBCs. Summary graphs of maximum depolarization (A) and repolarization (B) rates of first action potentials evoked by current injections in current-clamped wild type (n = 32, 15–20 slices, 5 animals, mean age P19) and Asic5 KO (n = 28, 12–15 slices, 4 animals, mean age P18) type II UBCs. *Significantly different using a t-test. (C) Overlay of representative first action potentials from current-clamped type II UBCs injected with 70 pA from wild type (black) and Asic5 KO (gray) mice. Summary graphs of mean thresholds (D), amplitudes (E), and half-widths (F) for first action potentials in type II UBCs evoked by 10 pA supra-threshold current injections in wild type (n = 13, 5 animals) and Asic5 KO (n = 8, 3 animals) mice. No value is significantly different.