Table 2.

Hit 2 Lead Performance Score (H2LPS).

Rank	Cat. No.	Compound	Cluster	EC50 screen	Fold diff	Curve shape score (0/1)	Upper-lower limits screen	EC50 score (1 to 4)	Fold diff score (0 to 2)	H2LPS*
1	S1045	Trichostatin A (TSA)	1	0.013	119.82	1	34.53	4	2	276.24
2	S2244	AR-42	4	0.369	14.72	1	59.94	2	2	239.76
3	S1515	Pracinostat (SB939)	4	0.558	59.25	1	56.37	2	2	225.48
4	S2170	Givinostat (ITF2357)	4	0.269	18.69	1	46.59	2	2	186.36
5	S1090	PCI-24781 (Abexinostat)	4	0.138	33.72	1	44.18	2	2	176.72
6	S1085	Belinostat (PXD101)	4	0.342	High	1	43.41	2	2	173.64
7	S7569	LMK-235	4	0.683	High	1	43.40	2	2	173.6
8	S8043	Scriptaid	3	2.438	High	1	62.01	1	2	124.02
9	S1030	Panobinostat (LBH589)	1	0.013	9.21	1	22.06	4	1	88.24
10	S2779	M344	3	3.218	2.54	1	74.15	1	1	74.15
11	S1194	CUDC-101	3	1.991	High	1	34.34	1	2	68.68
12	S7917	Kenpaullone	6	0.034	6.97	1	12.92	4	1	51.68
13	S7597	BV-6	6	0.099	High	1	7.00	3	2	42
14	S7198	BIO	6	0.125	3.01	1	12	2	1	24
15	S7648	OTS964	1			0		4	0	0
16	S1095	LAQ824 (Dacinostat)	1			0		4	0	0
17	S1096	Quisinostat (JNJ-26481585)	1			0		4	0	0
18	S3020	Romidepsin (FK228, Depsipeptide)	1			0		4	0	0
19	S3030	Niclosamide (Niclocide)	6			0		4	0	0
20	S7652	OTS514 hydrochloride	2			0		4	0	0
21	S2349	Rutaecarpine	6			0		4	0	0
22	S2892	VU 0361737	6			0		4	0	0
23	S2422	Ipriflavone (Osteofix)	6			0		4	0	0
24	S2759	CUDC-907	5			1		4	0	0
25	S7665	CH5183284 (Debio-1347)	6			0		4	0	0
26	S8376	Rbin-1	6			0		4	0	0
27	S7915	BIO-acetoxime	6	0.33	0.65	1	13.04	2	0	0

*H2LPS = Curve Shape Score * (Upper limit − Lower Limit) * EC50score * Fold Diff Score.