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. 2020 Feb 7;10:2114. doi: 10.1038/s41598-020-58845-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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NCOR/HDAC3 recruitment for transcriptional induction of gluconeogenesis pathway. Molecular models of NCOR/HDAC3 recruitment for gluconeogenesis transcriptional genes during fasting. (A) In present of NCOR/HDAC3 complex, gluconeogenesis activated via FOXO/Class IIa HDACs. (B) in absent of NCOR/HDAC3 complex, Class IIa HDACs lose it is ability to activate FOXO leading to suppress gluconeogenesis transregional genes.