Table 3.

Complement, leukocytes, and albumin in controls and necrotizing soft-tissue infection patients with and without septic shock.

Variable	Total (N = 135)	Controls (N = 65)	Non-shock (N = 39)	Septic shock (N = 96)	p-value
MASP-1, AU/L	7.6 [6.5–8.9]	8.7 [7.5–10.2]a	8.4 [6.8–9.3]	7.4 [6.3–8.7]b	0.0017
MASP-2, AU/L	793.4 [504.1–1121.0]	977.5 [623.3–1464.3]	905.1 [551.9–1422.5]	717.3 [487.6–1015.0]	0.0390
MASP-3, AU/L	65.4 [47.5–100.5]	109.3 [87.9–130.1]ca	65.4 [48.4–86.2]b	65.5 [46.5–113.7]b	<0.0001
C4, g/Ld	0.17 [0.14–0.24]	0.24 [0.20–0.31]ca	0.17 [0.14–0.26]b	0.17 [0.13–0.24]b	<0.0001
C4c AU/L	134.6 [87.3–199.0]	194.7 [130.9–326.5]a	158.2 [106.1–261.4]	125.9 [80.7–188.8]b	<0.0001
C4c/C4d	752.9 [507.1–1165.8]	855.3 [569.8–1391.0]	958.6 [522.1–1442.3]	671.5 [506.0–1086.0]	0.0828
C3, g/Ld	0.93 [0.75–1.2]	1.2 [1.1–1.4]ca	1.04 [0.82–1.4]ba	0.89 [0.73–1.08]bc	<0.0001
C3bc, AU/L	15.7 [9.2–24.2]14.7 [9.1–22.0]	12.5 [9.1–18.4]	17.0 [9.5–22.4]	15.6 [9.1–24.2]	0.2460
C3bc/C3d	16.5 [10.3–27.0]	10.7 [7.7,14.7]ca	15.2 [9.3,23.0]b	16.7 [10.4,27.3]b	0.0002
TCC AU/L	1.5 [1.00–2.6]	0.35 [0.26–0.46]ca	1.3 [0.68–1.8]ba	1.7 [1.1–2.8]bc	<0.0001
Leukocyte count, × 10/l, highest value	16.9 [10.4–23.9]	7.2 [6.3–9.3]ca	15.5 [9.7–22.7]b	17.6 [12.3–24.4]b	<0.0001
C-reactive protein, mg/Ld	222.0 [141.0–298.0]	2.0 [1.00–4.0]ca	201.0 [134.0–275.0]b	222.0 [154.0–301.5]b	<0.0001
Albumin, g/L	20.0 [16.0–22.0]	39.0 [36.0–41.0]ca	21.0 [18.0–23.0]b	18.5 [15.0–22.0]b	<0.0001

Values presented as Median [IQR] with Kruskal-Wallis test. A significance level of 0.0167 was used for pairwise ad-hoc comparisons. Septic shock defined by criteria of Bone et al. (18).

^aSignificantly different from Septic Shock.

^bSignificantly different from controls.

^cSignificantly different from non-shock.

^dData not available for all subjects. Missing values: C4 (n = 4), C4c/C4 (n = 4) C3 (n = 4), C3bc/c3 (n = 4), leukocyte count (n = 3), and CRP (n = 4).