Table 4.
Cox regression analyses for 90-day mortality.
| Unadjusted | Adjusted for sex, SAPS II | Adjusted for age, sex, chronic disease, and SAPS II | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variables grouped by their medians | HR | 95% CI | P-value | HR | 95% CI | P-value | HR | 95% CI | P-value | |
| MASP-1 | ≤7.63 AU/L | 1.000 | 1.000 | 1.000 | 0.0251 | |||||
| >7.63 AU/L | 0.372 | [0.171–0.808] | 0.0125 | 0.378 | [0.164–0.872] | 0.0226 | 0.368 | [0.153–0.882] | ||
| MASP-2 | ≤793.36 AU/L | 1.000 | 1.000 | 1.000 | 0.0936 | |||||
| >793.36 AU/L | 0.297 | [0.133–0.666] | 0.0032 | 0.475 | [0.202–1.119] | 0.0886 | 0.473 | [0.197–1.135] | ||
| MASP-3 | ≤65.39 AU/L | 1.000 | 1.000 | 1.000 | 0.3232 | |||||
| >65.39 AU/L | 1.133 | [0.560–2.291] | 0.7289 | 1.497 | [0.710–3.157] | 0.2896 | 1.466 | [0.686–3.133] | ||
| C4 | ≤0.17 g/L | 1.000 | 1.000 | 1.000 | 0.0003 | |||||
| >0.17 g/L | 0.215 | [0.088–0.525] | 0.0007 | 0.162 | [0.060–0.438] | 0.0003 | 0.158 | [0.057–0.434] | ||
| C4c | ≤134.63 AU/L | 1.000 | 1.000 | 1.000 | 0.9072 | |||||
| >134.63 AU/L | 0.371 | [0.171–0.806] | 0.0123 | 1.033 | [0.425–2.508] | 0.9437 | 1.056 | [0.424–2.631] | ||
| C4c/C4 | ≤752.86 | 1.000 | 1.000 | 1.000 | 0.0250 | |||||
| >752.86 | 1.473 | [0.722–3.007] | 0.2872 | 2.290 | [1.078–4.867] | 0.0312 | 2.543 | [1.124–5.755] | ||
| C3 | ≤0.93 g/L | 1.000 | 1.000 | 1.000 | 0.9437 | |||||
| >0.93 g/L | 0.434 | [0.204–0.921] | 0.0297 | 1.005 | [0.429–2.352] | 0.9911 | 1.032 | [0.433–2.460] | ||
| C3bc | ≤15.67 AU/L | 1.000 | 1.000 | 1.000 | 0.0132 | |||||
| >15.67 AU/L | 1.657 | [0.804–3.414] | 0.1708 | 2.664 | [1.195–5.938] | 0.0166 | 2.841 | [1.244–6.487] | ||
| C3bc/C3 | ≤16.49 | 1.000 | 1.000 | 1.000 | 0.0017 | |||||
| >16.49 | 3.283 | [1.468–7.344] | 0.0038 | 4.041 | [1.673–9.758] | 0.0019 | 4.301 | [1.730–10.697] | ||
| TCC | ≤1.55 AU/L | 1.000 | 1.000 | 1.000 | 0.1236 | |||||
| >1.55 AU/L | 0.961 | [0.475–1.945] | 0.9130 | 0.564 | [0.267–1.192] | 0.1338 | 0.554 | [0.261–1.175] | ||
Values are presented as Hazard ratios (HR) with 95% confidence intervals (95% CI) and p-values. Complement factors are divided according to median values with below median group as references. SAPS II, Simplified Acute Physiology Score II.