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. 2020 Feb 7;21:29. doi: 10.1186/s13059-020-1946-2

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — African ancestry enrichment at the major histocompatibility complex (MHC) locus. a Manhattan plot showing the statistical significance of African ancestry enrichment across the genome. b Haplotype on chromosome 6 with significant African ancestry enrichment for three of the four LA populations: Colombia, Mexico, and Puerto Rico. This region corresponds to the largest peak of African ancestry enrichment on chromosome 6 seen in a. Population-specific African (blue), European (orange), and Native American (red) ancestry enrichment values (z_anc) are shown for chromosome 6 and the MHC locus. c Integrated haplotype score (iHS) values for African continental population from the 1KGP are shown for the MHC locus; peaks correspond to putative positively selected human leukocyte antigen (HLA) genes.