Table 2.
Co-receptor prediction using sequences from HIV-1 subtype C mother-to-child and heterosexual transmissions
| Predicted biotype | ||||||
|---|---|---|---|---|---|---|
| Early | Chronic | |||||
| Total (%) | X4 (%) | R5 (%) | Total (%) | X4 (%) | R5 (%) | |
| Mother-to-child transmission | ||||||
| Total sequence | 1052 | 46 (4.4%; 95% CI − 1.5 to 6.5) | 1006 (95.6%; 95% CI 93.5, 101.5) | 2115 | 143 (6.8%; 95% CI − 10.9 to 31.5) | 1972 (93.2%; 95% CI 68.5–110.9) |
| Malawi (MW) | 691 (65.6) | 41 (5.9) | 650 (94.1) | 1693 (80) | 63 (3.7) | 1630 (96.3) |
| South Africa (ZA) | 11 (1.1) | 0 | 11 (100) | 151 (7.1) | 61 (40.4) | 90 (59.6) |
| Tanzania (TZ) | 49 (4.7) | 3 (6.1) | 46 (93.9) | 1 (0.04) | 0 | 1 (100) |
| Zambia (ZM) | 297 (28.2) | 2 (0.7) | 295 (99.3) | 263 (12.4) | 19 (7.2) | 244 (92.8) |
| Zimbabwe (ZW) | 4 (0.4) | 0 | 4 (100) | 7 (0.33) | 0 | 7 (100) |
| Heterosexual transmission | ||||||
| Total sequences analyzed | 3289 | 385 (11.7%; 95% CI − 1.8 to 13.9) | 2904 (88.3%; 95% CI 86.4–101.8) | 2480 | 231 (9.3%; 95% CI − 0.9 to 13.5) | 2249 (90.7%; 95% CI 86.5–100.9) |
| Botswana (BW) | 29 (0.9) | 1 (3.4) | 28 (96.6) | 4 (0.16) | 0 | 4 (100) |
| Ethiopia (ET) | 1 (0.03) | 0 | 1 (100) | 10 (0.4) | 0 | 10 (100) |
| Kenya (KE) | 1 (0.03) | 0 | 1 (100) | 22 (0.7) | 0 | 22 (100) |
| Malawi (MW) | 1237 (37.6) | 274 (28.5) | 963 (71.5) | 856 (34.3) | 89 (11) | 762 (89) |
| Rwanda (RW) | 96 (2.9) | 0 | 96 (100) | 6 (0.2) | 0 | 6 (100) |
| South Africa (ZA) | 927 (28.2) | 66 (7.1) | 861 (92.9) | 506 (20.4) | 19 (3.6) | 487 (96.4) |
| Tanzania (TZ) | 36 (1.1) | 2 (5.5) | 34 (94.5) | 174 (7) | 55 (32.4) | 119 (67.6) |
| Uganda (UG) | NA | NA | NA | 1 (0.04) | 0 | 1 (100) |
| Zambia (ZM) | 962 (29.3) | 42 (4.4) | 920 (95.6) | 875 (35.3) | 61 (7) | 814 (93) |
| Zimbabwe (ZW) | NA | NA | NA | 26 (1) | 2 (8.3) | 24 (91.7) |
NA not available