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. 2020 Feb 7;17:52. doi: 10.1186/s12974-020-1729-4

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — The Cx3cr1-Dtr rat allows selective inducible ablation of microglia. Numbers of microglia were reduced throughout the hippocampus by 48 h after diphtheria toxin in Cx3cr1-Dtr rats compared to wild-types (wt) with microglia repopulating the hippocampus by 7 days (n = 5–8 per group). a, b CA1 (significant genotype by day interaction: F_{(2, 31)} = 6.61, p = 0.004); c, d CA3 (interaction: F_{(2, 35)} = 6.66, p = 0.004); e, f hilus (interaction: F_{(2, 34)} = 3.53, p = 0.040); g, h subgranular/granular (significant effect of day: F_{(1, 35)} = 10.43, p < 0.001); or i, j molecular (interaction: F_{(2, 34)} = 6.61, p = 0.004) regions of the dentate gyrus. *p < 0.05 with Tukey post hoc tests. $ significant main effect of day (recovery time). Data are expressed as mean ± SEM. Scale bars = 10 μm