Table 4.

Regression coefficients of our integrated prognostic model

Covariate	Coefficient ± SE	HR	95% CI	P
T stage
T1		1
T2	−3.125 ± 1.253	0.0439	0.00377–0.513	0.0127
T3	−1.186 ± 0.810	0.305	0.0624–1.493	0.143
T4a	−0.298 ± 1.069	0.742	0.0913–6.033	0.780
T4b	0.530 ± 1.152	1.699	0.178–16.241	0.646
N stage
N0		1
N1a	0.266 ± 0.504	1.305	0.486–3.506	0.598
N1b	0.175 ± 0.450	1.191	0.493–2.877	0.697
N2a	1.355 ± 0.396	3.876	1.785–8.416	0.0006
N2b	0.985 ± 0.468	2.679	1.071–6.703	0.0352
M stage
M0		1
M1	1.644 ± 0.362	5.178	2.546–10.532	5.64 e-6
Age
31–58		1
59–70	0.654 ± 0.449	1.923	0.798–4.635	0.145
70–78	1.045 ± 0.411	2.842	1.269–6.363	0.0111
79–90	1.244 ± 0.382	3.469	1.641–7.333	0.0011
Gene Expression
Cluster1		1
Cluster2	0.970 ± 0.454	2.638	1.083–6.429	0.0328
Cluster3	2.404 ± 0.551	11.067	3.758–32.591	1.28 e-5
Cluster4	0.597 ± 1.160	1.817	0.187–17.641	0.606
DNA Methylation
Cluster1		1
Cluster2	−0.138 ± 0.576	0.871	0.281–2.695	0.811
Cluster3	0.764 ± 0.577	2.146	0.693–6.645	0.185
Cluster4	0.352 ± 0.465	1.423	0.572–3.539	0.449
Cluster5	−0.132 ± 0.667	0.876	0.237–3.239	0.843
Cluster6	−0.895 ± 0.604	0.409	0.125–1.336	0.139
Cluster7	− 0.397 ± 0.673	0.672	0.180–2.514	0.555
Cluster8	−1.960 ± 1.128	0.141	0.0155–1.284	0.0822
Cluster9	−1.848 ± 0.809	0.157	0.0323–0.769	0.0223
Cluster10	−1.015 ± 0.732	0.362	0.0863–1.521	0.165
miRNA Expression
Cluster1		1
Cluster2	0.527 ± 0.341	1.693	0.867–3.305	0.123
Cluster3	0.276 ± 0.450	1.318	0.546–3.182	0.539
Cluster4	−0.669 ± 0.503	0.512	0.191–1.373	0.184

Origin concordance: 0.8345; bias-corrected concordance: 0.7604

SE standard error, HR hazard ratio, CI confidence interval