Table 6.

Wilcoxon signed-rank test of difference in C-index distribution between our prognostic model and other models

Comparison	P value of the 2-year C-index	P value of the 3-year C-index	P value of the 5-year C-index	P value of the bootstrap results
CGMm vs CMm	<  2.2 e-16	<  2.2 e-16	<  2.2 e-16	<  2.2 e-16
CGMm vs CGM	<  2.2 e-16	<  2.2 e-16	<  2.2 e-16	1.091 e-5
CGMm vs CGm	<  2.2 e-16	<  2.2 e-16	<  2.2 e-16	0.000102
CGMm vs CA	<  2.2 e-16	<  2.2 e-16	<  2.2 e-16	5.028 e-12
CGMm vs CG	<  2.2 e-16	<  2.2 e-16	<  2.2 e-16	<  2.2 e-16
CGMm vs CM	<  2.2 e-16	<  2.2 e-16	<  2.2 e-16	<  2.2 e-16
CGMm vs Cm	<  2.2 e-16	<  2.2 e-16	<  2.2 e-16	<  2.2 e-16
CGMm vs C	<  2.2 e-16	<  2.2 e-16	<  2.2 e-16	<  2.2 e-16
CGMm vs G	<  2.2 e-16	<  2.2 e-16	<  2.2 e-16	<  2.2 e-16
CGMm vs M	<  2.2 e-16	<  2.2 e-16	<  2.2 e-16	<  2.2 e-16
CGMm vs m	<  2.2 e-16	<  2.2 e-16	<  2.2 e-16	<  2.2 e-16
CMm vs CG	<  2.2 e-16	<  2.2 e-16	<  2.2 e-16	0.0209
CMm vs Cm	<  2.2 e-16	<  2.2 e-16	<  2.2 e-16	0.00161
CMm vs C	<  2.2 e-16	<  2.2 e-16	<  2.2 e-16	1.452 e-7
CG vs C	<  2.2 e-16	<  2.2 e-16	<  2.2 e-16	<  2.2 e-16
Cm vs C	3.413 e-16	<  2.2 e-16	0.00323	7.012 e-13

In the Comparison column, C stands for clinical, G for gene expression, M for DNA methylation and m for miRNA expression. The words on both sides of vs are the covariates in the prognostic model