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. Author manuscript; available in PMC: 2020 Nov 27.
Published in final edited form as: Cell. 2019 Nov 21;179(6):1357–1369.e16. doi: 10.1016/j.cell.2019.10.035

Figure 7. Model for nascent 3’domain assembly in absence of assembly factors.

Figure 7.

Nascent RNA molecules can either misfold (shown in red) into stable non-native structures (deep valley on the left) or fold into RNA molecules that eventually transition into S7 binding competent conformations. The r-proteins chaperone the rRNA folding process early in assembly prior to their stable incorporation into the growing RNP particle. Nascent RNA folding and assembly are slow due to the rugged energy landscape. Progressive binding of r-proteins facilitates folding and stabilizes the nascent RNA. The single-molecule traces on the bottom demonstrate the decreasing protein binding dynamics during assembly.