Figure 1.

Batokine-mediated processes during brown adipose tissue (BAT) recruitment. Adipose tissue is composed of mature adipocytes (20% to 30%) and a stromal vascular fraction with a dynamic composition of preadipocytes, endothelial cells, hematopoietic cells and neural cells. Batokines are produced by the mature brown adipocytes and can (1) act on other tissues in an endocrine fashion; (2) enhance thermogenic activity; (3) induce processes involved in BAT recruitment including adipogenesis, angiogenesis, immunometabolism, neurite outgrowth.