Table 2.
Diagnostic performance
AUC | 95% CI | Sensitivity | Specificity | PPV | NPV | Accuracy | |
---|---|---|---|---|---|---|---|
MUC5AC | |||||||
PC vs. controls | 0.825 | 0.760–0.890 | 0.541 | 0.951 | 0.846 | 0.807 | 0.815 |
EPC vs. controls | 0.793 | 0.695–0.890 | 0.500 | 0.951 | 0.714 | 0.886 | 0.863 |
LPC vs. controls | 0.856 | 0.783–0.930 | 0.581 | 0.951 | 0.75 | 0.900 | 0.877 |
CA19-9 | |||||||
PC vs. controls | 0.836 | 0.770–0.902 | 0.820 | 0.618 | 0.515 | 0.874 | 0.685 |
EPC vs. controls | 0.844 | 0.752–0.937 | 0.833 | 0.618 | 0.347 | 0.938 | 0.660 |
LPC vs. controls | 0.827 | 0.740–0.914 | 0.806 | 0.618 | 0.347 | 0.927 | 0.656 |
Combination | |||||||
PC vs. controls | 0.894 | 0.844–0.943 | 0.738 | 0.886 | 0.763 | 0.872 | 0.837 |
EPC vs. controls | 0.892 | 0.819–0.966 | 0.767 | 0.886 | 0.622 | 0.940 | 0.863 |
LPC vs. controls | 0.895 | 0.837–0.954 | 0.710 | 0.886 | 0.611 | 0.924 | 0.851 |
AUC area under receiver operating characteristic curve, EPC early-stage pancreatic cancer, LPC late-stage pancreatic cancer, NPV negative predictive value, PC pancreatic cancer, PPV positive predictive value