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. 2020 Feb 7;21:132. doi: 10.1186/s12864-020-6550-z

Table 4.

List of genes involved in insulin signalling pathway of Pde6c mutant zebrafish (p-value = 5.64e-03; FDR = 9.83e-02)

Ref mRNA Gene Symbol Gene Name logFC p-value
NM_001004527 ppp1cb protein phosphatase 1, catalytic subunit, beta isozyme −13.3391067 5.63E-09
NM_131855 prkci protein kinase C, iota −11.4865862 4.49E-05
NM_213075 flot2a flotillin 2a −11.94140373 7.05E-06
NM_001142672 insra insulin receptor a −4.775105577 2.21E-05
NM_001123229 insrb insulin receptor b −11.53691235 3.33E-05
NM_131381 gsk3b glycogen synthase kinase 3 beta −11.65098191 1.87E-05
NM_199570 calm3b calmodulin 3b (phosphorylase kinase, delta) −14.42999547 1.49E-11
NM_001077211 mtor mechanistic target of rapamycin (serine/threonine kinase) −12.74710586 1.23E-07
NM_212710 ppp1cab protein phosphatase 1, catalytic subunit, alpha isozyme b −4.868811067 1.31E-05
NM_199996 calm2a calmodulin2a (p hosphorylase kinase, delta) −13.04988312 3.41E-08
NM_194402 mknk2b MAP kinase interacting serine/threonine kinase 2b −14.02356489 1.26E-10
NM_214751 pck1 phosphoenolpyruvate carboxykinase 1 (soluble) 5.129531889 7.55E-09
NM_200315 irs2a insulin receptor substrate 2a −12.51373347 4.75E-07
NM_201023 prkacba protein kinase, cAMP-dependent, catalytic, beta a 4.638063399 9.62E-09
NM_205744 braf B-Raf proto-oncogene, serine/threonine kinase −11.88966935 5.38E-06
NM_213035 grb2b growth factor receptor-bound protein 2b −12.43630299 7.66E-07
NM_213076 rps6kb1b ribosomal protein S6 kinase b, polypeptide 1b −11.31030831 6.05E-05
NM_213161 prkag1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit −11.20468266 0.000101616
NM_213252 hk1 hexokinase 1 −13.41102831 3.67E-09
NM_001017732 prkar1ab protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) b −11.53493265 3.59E-05
NM_001077370 prkar2aa protein kinase, cAMP-dependent, regulatory, type II, alpha A −4.330637539 1.19E-05
NM_001281844 pik3r1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) −13.92572365 2.37E-10
NM_131721 mapk8b mitogen-activated protein kinase 8b −5.355743879 1.18E-06
NM_001080066 g6pc3 glucose 6 phosphatase, catalytic, 3 4.465924297 9.85E-08