Table 3.

Overview of the predictors used for predictive models and nested models

	Non-personalized model	Prognostic model	Predictive model
Clinical site	x	x	x
Index therapy	x	x	x
Index duration	x	x	x
Age		x	x
Gender		x	x
EDSS		x	x
Second-line		x	x
Current therapy		x	x
Current duration		x	x
Interaction (Current therapy, Current duration)		x	x
Diagnosis distance		x	x
Relapse distance		x	x
Relapses count		x	x
DMTs count		x	x
Interaction (Index therapy, Diagnosis distance)			x
Interaction (Index therapy, Gender)			x
Interaction (Index therapy, Relapses count)			x
Interaction (Index therapy, Second-line)			x

EDSS expanded disability status scale, DMT disease modifying therapy, Second-line DMT to be employed by label of the European Medical Agency if previous DMT failed to achieve sufficient control of disease activity.