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. 2020 Feb 7;17:5. doi: 10.1186/s12014-020-9269-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Candidate proteins to classify ALK + NSCLC patients by duration of response to crizotinib. a Venn Diagram of the protein list identified with both methods (differential expression = DE, classifier = P) and both comparisons (Long vs Normal and Long vs Poor). Kaplan–Meier plots where patients were separated in two groups based on the median expression value of DPP4 (b) or FCGBP (c) two of the top contributing protein in long versus normal panel analysis. d–f Normalized log2LH ratio of three proteins (DPP4, LUM, KIT) in each of the response groups. g ROC curve of one of the best panels obtained in long versus normal comparison which includes DPP4, FCGBP and LUM