Table 2.
Hemodynamic and cardiac functional parameters according to the BMPR2 mutations of pulmonary hypertension
| Variables | Mutations | Non-mutations | MD/OR(95%CI) | P value |
|---|---|---|---|---|
| Age at diagnosis (yrs) | 35.12 ± 12.79 (556) | 40.17 ± 16.25 (1174) | −3.70 [−6.52, −0.87] | <0.00001 |
| 6MWD (m) | 363.12 ± 113.97 (332) | 369.22 ± 116.82 (863) | −14.81 [−45.24, 15.62] | 0.34 |
| mPAP (mmHg) | 61.21 ± 12.73 (570) | 56.37 ± 14.08 (1197) | 4.82 [2.38, 7.25] | 0.0001 |
| PVR (Wood units) | 18.65 ± 8.69 (557) | 15.11 ± 7.8 (1166) | 3.90 [3.23, 4.57] | <0.000 |
| CI (L/ml/m2) | 2.08 ± 0.65 (547) | 2.51 ± 0.86 (1156) | −0.44 [−0.63, − 0.24] | <0.000 |
| RVP (mmHg) | 8.30 ± 4.99 (405) | 7.41 ± 5.60, 835 (835) | −0.32 [− 0.91, 0.27] | 0.29 |
| NYHA III | 67.95% (312) | 70.22% (648) | 0.84 [0.62, 1.14] | 0.26 |
| NYHA IV | 11.54% (312) | 6.94% (648) | 1.71 [1.07, 2.72] | 0.02 |
6MWD 6 min walk distance, mPAP mean PAP, PVR pulmonary vascular resistance, CI cardiac index, RVP right ventricular pressure; these results are expressed as mean ± SD. NYHA new york heart association functional classification, expressed as % (patients number); MD mean difference, OR odd ratio, 95% CI 95% confidence interval