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. 2020 Feb 7;21:26. doi: 10.1186/s13059-020-1937-3

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Long and nearly perfect duplexes are extremely rare. a Number of genomic nucleotides within putative dsRNAs (IDS) and control (TDS) regions, summed over all organisms, as a function of the region length (right) and the similarity (left), for both mRNA (top) and pre-mRNA (bottom). Note the logarithmic scale. For regions longer than 300 bp and of very high identity, the depletion of putative dsRNAs becomes more pronounced, even in pre-mRNAs. b Comparison of long (> 300), nearly perfect (> 96%), inverted duplicated sequences (potentially folding into dsRNA; red) to tandem duplicated sequences (control; blue) across a wide range of organisms, for pre-mRNA molecules. In most organisms, these putative dsRNA structures are completely depleted. Gray indicates no data (zero IDS and zero TDS). c In mRNA, there are only 4 long and nearly perfect structures in all organisms combined (2419 bps), compared with 258 control TDSs (172,326 bps)