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a) The potent tubulin inhibitor colchicine as a lead scaffold led to the development of the HOTub generation of HTI-based antimitotics (e.g., HOTub-31). Changing the lead scaffold to indanocine led to the development of up to ten times more potent HITubs (e.g., HITub-4). b) Straightforward, short, and high-yielding synthesis of HITub-4.
