Table 1.
Significant results (P-value < 0.002) of association tests for the FTO variant rs1421085 (with C as the effect allele) with phenotype traits, using genetic model based on additive mode of inheritance (TT versus TC versus CC).
| Trait | Adjustments | Effect size (Beta value) | P-value | Pemp-value |
|---|---|---|---|---|
| SLM | R | 2.249 | 0.00103 | 0.055 |
| R+DM | 2.402 | 0.00030 | 0.017 | |
| R+LLM | 2.265 | 0.00066 | 0.033 | |
| TBW | R | 1.796 | 0.00103 | 0.055 |
| R+DM | 1.920 | 0.00029 | 0.016 | |
| R+LLM | 1.808 | 0.00066 | 0.037 | |
| Weight | R | 3.953 | 0.00221 | 0.114 |
| R+DM | 4.566 | 0.00030 | 0.018 | |
| R+LLM | 4.374 | 0.00054 | 0.031 |
Association tests were adjusted for age, sex (R), and further confounders such as diabetes medication (DM) and lipid lowering medication (LLM). Results of association tests with other traits showing a P-value of ≤ 0.05 are given in Supplementary Table S2 .