Table 2.
Linear regression model illustrating the link between the FTO variant rs1421085 and interaction between soft lean mass (SLM), total body water (TBW), and weight with ghrelin, ApoA1, and ApoB48.
| Trait (response/dependent variable) | Genotype and/or interacting trait (Predict variable) | Estimate | Std. Error | P-value | Adjusted R-square (model) |
|---|---|---|---|---|---|
| SLM (TT count: 62; TC+CC count: 116) |
TC+CC | 8.161 | 3.259 | 0.013 | 0.587 |
| TC+CC*ghrelin | -0.010 | 0.005 | 0.041 | ||
| SLM | TC+CC | 10.68 | 2.912 | 0.00036 | 0.663 |
| TC+CC*ApoA1 | -9.34E-07 | 3.56E-07 | 0.0098 | ||
| SLM | TC+CC | 9.51 | 2.85 | 0.0016 | 0.687 |
| TC+CC*ApoB48 | -9.15E-05 | 4.27E-05 | 0.034 | ||
| TBW (TT count: 62; TC+CC count: 116) |
TC+CC | 6.533 | 2.61 | 0.013 | 0.562 |
| TC+CC*ghrelin | -0.0085 | 0.004 | 0.042 | ||
| TBW | TC+CC | 8.54 | 2.313 | 0.00033 | 0.646 |
| TC+CC*ApoA1 | -7.47E-07 | 2.83E-07 | 0.0094 | ||
| TBW | TC+CC | 7.63 | 2.269 | 0.0015 | 0.671 |
| TC+CC*ApoB48 | -7.35E-05 | 3.4E-05 | 0.032 | ||
| Weight (TT count: 93; TC+CC count: 178) |
TC+CC | 15.55 | 6.514 | 0.018 | 0.162 |
| TC+CC*ghrelin | -0.017 | 0.011 | 0.109 | ||
| Weight | TC+CC | 0.225 | 5.95 | 0.0002 | 0.304 |
| TC+CC*ApoA1 | -2.05E-06 | 7.64E-07 | 0.0081 | ||
| Weight | TC+CC | 9.71 | 5.41 | 0.074 | 0.221 |
| TC+CC*ApoB48 | -5.25 | 7.98E-05 | 0.511 |
*Results are shown for carrier genotypes regressed against the reference TT genotype. Genetic model was based on dominant mode of inheritance since interactions involving genotypes carrying the effect allele (TC and CC) versus reference genotype (TT) were examined.