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Col2; PRcKO male mice had higher cellular senescence at the subchondral bone regions.
Distal femurs from both female and male 4-month-old WT and Col2; PRcKO mice were stained with anti-p16INK4a (stained in green, white arrowheads) and MMP13 (stained in red). Some of the chondrocytes expressed both p16INK4a and MMP13 (yellow arrowheads). Scale bar 10μm. N=5-8/group.
