Cumulative exposure is modeled as a time-dependent categorical variable. The model is further adjusted for a propensity score incorporating study cohort (SPRINT vs. ACCORD), age, sex, history of clinical cardiovascular disease, smoking status, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, glucose, estimated glomerular filtration rate and assignment to intensive vs. standard glycemia treatment. aTRH, apparent treatment-resistant hypertension; CV, cardiovascular; HF, heart failure; MI, myocardial infarction; PS, propensity score