Figure 7. A20 in CD11c⁺ myeloid cells suppresses the hypertensive response via a T cell-dependent mechanism.

(A) Mean arterial pressures measured by radio-telemetry in Rag1^−/−mice (“Rag1^−/−”, open circles) and Rag1^−/− Cd11c-Cre⁺ A20^flox/wt (“Rag1^−/− DC ACT”, open squares) mice at baseline (“pre”) and during chronic Ang II infusion. Comparisons between the groups were performed using the two-way ANOVA. (B) Ratio of heart weight/body weight (mg/g) in the Rag1^−/− and Rag1^−/−DC ACT groups after 28 days of Ang II infusion. N=5–6 mice/group. Statistical significance was assessed using an unpaired Student’ t-test. Data are mean ± SE.