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. Author manuscript; available in PMC: 2020 Dec 6.
Published in final edited form as: Circ Res. 2019 Oct 21;125(12):1055–1066. doi: 10.1161/CIRCRESAHA.119.315343

Figure 8. A role for A20 in dendritic cells (DCs) to protect against Ang II-induced hypertension.

Figure 8.

A20 in DCs inhibit IkB kinase and NF-ĸB activation, which limits the maturation of DCs. In response to Ang II, DCs are recruited to the kidney where they mature and are exposed to antigens. In the renal lymph nodes, activated DCs expressing co-stimulatory molecules prime T lymphocytes that further circulate in the kidney and release pro-hypertensive cytokines. Pro-hypertensive cytokines such as TNF-α, IFN-γ, and IL-17A increase sodium transporter expression and reduce blood flow in the kidney to drive volume retention and blood pressure elevation.