Figure 1. . Cartoon depicting antigens and receptors abundant on Treg cells.
CD3: T cell co-receptor which associates with the T cell receptor (TCR) and ζ-chain (zeta-chain) to generate the TCR complex that leads to T cell activation; CD4: Glycoprotein originally known as leu-3 or T4; CD25: IL-2 receptor alpha chain; CTLA4: Cytotoxic T-lymphocyte-associated protein 4 (also known as CD152); FoxP3, forkhead box protein P3; GITR, glucocorticoid-induced TNFR-related protein; LAG3: Lymphocyte-activation gene 3; PD1: Programmed cell death protein 1 (also known as CD279); TIM3: T-cell immunoglobulin and mucin-domain containing-3; TIGIT: T cell immunoreceptor with Ig and ITIM domains.