Table 1. . Mixed-effect linear regression models for the longitudinal effects of different treatments on tumor volumes for cutaneous squamous cell carcinoma.

Solution for fixed effects
Effect		Estimate	Standard error	t value	Pr > |t|	F value	Pr > F
Time						56.75	<0.0001
	2	0	–	–	–
	4	0.1107	0.06756	1.64	0.1038
	6	0.1979	0.06696	2.96	0.0037
	8	0.3014	0.06594	4.57	<0.0001
	10	0.4474	0.06416	6.97	<0.0001
	12	0.5511	0.06103	9.03	<0.0001
	14	0.6940	0.05529	12.55	<0.0001
	16	0.8357	0.04387	19.05	<0.0001
Cu-Cy NPs		-0.3688	0.08301			19.73	0.0005
X-ray		-0.1834	0.08544			4.61	0.0486
Cu-Cy NPs * x-ray		0.03859	0.1161			0.11	0.7441
Volume at irradiation		2.1729	1.7740			1.50	0.2395

Cu-Cy NP: Copper-cysteamine nanoparticle.