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. 2019 Jun 10;14(16):2209–2226. doi: 10.2217/nnm-2019-0086

Figure 3. . Superparamagnetic iron oxide nanoparticles effect on liver-specific functions of 3-day short-term primary rat hepatocyte cultures.

Figure 3. 

Figure 3. 

Albumin (A) and urea (B) assays to quantify the specific function of the primary rat hepatocytes for forty-eighth and seventy-second hour after the seeding (twenty-fourth and forty-eighth hour after the start of treatment with superparamagnetic iron oxide nanoparticles [SPION] in 50 and 100 μg/ml). Significant difference between well static model and chip is denoted as **p-value < 0.01; between chip static model and chip with flow is denoted as #p-value < 0.05 and ##p-value < 0.01. Statistical analyses among the flow groups: (A) forty-eighth hour: SPION (50 μg/ml) treatment: p > 0.05 for 25 versus 50 μl/h; p < 0.01 for 25 versus 100 μl/h; p < 0.05 for 50 versus 100 μl/h; SPION (100 μg/ml) treatment: p < 0.01 for 25 versus 50 μl/h; p < 0.05 for 25 versus 100 μl/h; p > 0.05 for 50 versus 100 μl/h; seventy-second hour: SPION (50 μg/ml) treatment: p > 0.05 between any two flow rates; SPION (100 μg/ml) treatment: p < 0.05 for 25 versus 50 μl/h and for 50 versus 100 μl/h; p < 0.01 for 25 versus 100 μl/h; (B) forty-eighth hour: SPION (50 μg/ml) treatment: p > 0.05 for 25 versus 50 μl/h; p < 0.05 for 25 versus 100 μl/h; p < 0.01 for 50 versus 100 μl/h; SPION (100 μg/ml) treatment: p < 0.01 for 25 versus 50 μl/h; p < 0.05 for 25 versus 100 μl/h; p > 0.05 for 50 versus 100 μl/h; seventy-second hour: SPION (50 μg/ml) treatment: p > 0.05 between any two flow rates; SPION (100 μg/ml) treatment: p < 0.01 for 25 versus 50 μl/h and for 25 versus 100 μl/h; p > 0.05 for 50 versus 100 μl/h.

SPION: Superparamagnetic iron oxide nanoparticles.