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. 2020 Jan 22;58(1):116–123. doi: 10.1080/13880209.2019.1711135

Figure 1.

Figure 1.

Effect of sildenafil on pulmonary hypertension, right heart hypertrophy and pulmonary vascular remodeling. Mean pulmonary artery pressure (mPAP), pulmonary artery systolic pressure (PASP) and pulmonary artery diastolic pressure (PADP) were shown in (A1). The ratio of right ventricular (RV) mass to left ventricular plus septum (LV + S) mass was shown in (A2). Percentage of nonmuscular (non), partially muscular (partial) and fully muscular (full) pulmonary arteries related to the total number of pulmonary arteries was shown in (B1). Percentage of vascular wall thickness (WT) and medial wall thickness (MT) related to vascular external diameter was shown in (B2). Percentage of lumen area (LA) related to complete vascular area (CSA) was shown in (B3). The above data were presented as mean ± SD; n = 10/group, except n = 5 in A1; *p < 0.05 vs. smoke and bacteria exposed group (Model group); **p < 0.01 vs. Model group. Representative photomicrographs of vascular remodeling stained by Victoria blue stain were shown in (C1, C2, and C3), with scale bars = 40 μm. Representative photomicrographs of vascular remodeling stained by hematoxylin and eosin stain were shown in (D1, D2, and D3), with scale bars = 160 μm, and were shown in (E1, E2, and E3), with scale bars = 40 μm.