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. 2020 Jan 31;11:93. doi: 10.3389/fimmu.2020.00093

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Copyright © 2020 Koeninger, Armbruster, Brinch, Kjaerulf, Andersen, Langnau, Autenrieth, Schneidawind, Stange, Malek, Nordkild, Jensen and Wehkamp.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protective effect of hBD2 in T cell transfer colitis. Colitis was induced by transferring CD4⁺/CD25⁻ T cells from WT mice to SCID mice. Development of colitis was observed for 94 days. Daily treatment with hBD2 (0.1 mg/kg or 1 mg/kg, s.c.) and Dexamethasone (0.3 mg/kg, i.p.) started 7 days after the transfer. (A) Weight change of mice during the experiment was monitored as well as (B) development of clinical symptoms as DAI. (C) Alteration of stool consistency was assessed as stool score. At the end of the experiment (D) colon weight was measured and (E) activity of myeloperoxidase (MPO) was quantified. (F) Representative images from the colon of differentially treated mice are shown. Results are presented as mean ± SEM, n = 6 (sham treated animals), n = 10 (vehicle and dexamethasone mice) and n = 11 (hBD2 mice). Appropriate statistical comparisons are shown within the graph by a Kruskal-Wallis-test for non-parametric data with a Dunn's post-test.