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Clinical symptoms after subcutaneous administration of hBD2.
| Test compound | Dose level mg/kg | Clinical signs on the day of dosing | Necropsy | |||
|---|---|---|---|---|---|---|
| No clinical signs | Pruritus | Clinical signs | Clinical signs at the end of the day of dosing | Macroscopic findings | ||
| Vehicle | 0 | 3/3 | 0/3 | 0/3 | 0/3 | 0/3 |
| HBD2 | 0.5 | 3/3 | 0/3 | 0/3 | 0/3 | 0/3 |
| 10 | 0/3 | 3/3 | 3/3 | 0/3 | 0/3 | |
| 40 | 0/3 | 3/3 | 3(severe)/3 | 0/3 | 0/3 | |
