Figure 4. . An overview of several possible drug targets (bold inside the dotted box) in Leishmania species, which can be targeted through nanoformulations.

Glyoxalase system, sterol biosynthesis pathway, ascorbate biosynthesis pathway, purine salvage pathway, protein kinases and proteases are some of the important and possible drug targets that may affect the parasite.

APRT: Adenine phosphoribosyltransferase; CDK: Cyclin-dependent kinase; HGPRT: Hypoxanthineguanine phosphoribosyltransferase; MAPKK: MAPK kinase, MAPKKK: MAPK kinase kinase; XPRT: Xanthine phosphoribosyltransferase.