Figure 4.

Estimates of relative risk across different adjustment methods comparing external control analysis to trial result: randomized controlled trial NCT0236143. To achieve greater balance among baseline covariates for PS analysis methods—“PS IPTW,” “PS Cox Adjustment,” and “PS Stratification”—PS were trimmed by removing nonoverlapping observations from the PS distributions of the experimental and controls arms resulting in slightly modified cohorts in both arms. HR, hazard ratio; IPTW, inverse probability of treatment weighting. LL, lower limit; PS, propensity score; UL, upper limit.