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. 2019 Sep 6;91(19):12246–12254. doi: 10.1021/acs.analchem.9b02075

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Copyright © 2019 American Chemical Society

This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.

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(a) Mean TWIMS drift time profiles obtained following LESA of native myoglobin (holo-) protein spots sampled under native conditions for various dwell times and mean TWIMS drift time profiles obtained following direct infusion electrospray of myoglobin (holo-) under native conditions (orange line) for 7+, 8+, and 9+ charge states. (b) Mean TWIMS drift time profiles of native myoglobin (holo-) protein spots sampled under native conditions following different drying times at 40 s dwell time and mean TWIMS drift time profiles obtained following direct infusion electrospray of holo-myoglobin (orange line) for 7+, 8+, and 9+ charge states. (c) Mean TWIMS drift time profiles of native myoglobin (holo-) droplets sampled with “liquid LESA” under native conditions at different dwell times and mean TWIMS drift time profiles obtained following direct infusion electrospray of native myoglobin (holo-) (orange line) for 7+, 8+, and 9+ charge states.) (d) Mean TWIMS drift time profiles of denatured myoglobin (apo-) protein spots sampled under native conditions for various dwell times and mean TWIMS drift time profiles obtained following direct infusion electrospray of myoglobin (apo-) under denaturing conditions (orange line) for 7+, 8+, and 9+ charge states.