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The change of Clinical Global Impression-severity (CGI-S) score during the study. p = 0.046, p = 0.317, p = 0.157, and p = 0.008 between baseline to month 3, month 3 to month 6, month 6 to month 12, and baseline to month 12, respectively, Wilcoxon Signed Rank test; Time effect, df = 3, F = 3.182, p = 0.055, one way General Linear Model.
