Skip to main content
. 2019 Jul 18;58(47):4696–4709. doi: 10.1021/acs.biochem.9b00453

Figure 1.

Figure 1

Talin serves as a force-dependent mechanochemical switch. Talin (gray) is shown bound to integrin and to F-actin. The 13 rod domains are shown arranged like beads on a string. The switch behavior of the R3 domain is shown. The left panel shows the talin–RIAM–Rap1 linkage. The inset shows the schematics of RIAM binding to folded talin R3. The right panel shows the talin–vinculin–F-actin linkage. The inset shows the schematics of full-length vinculin bound to exposed VBS in unfolded talin R3.