Table 1.

Genes disrupted by 2 or more LoF de novo variants. Individual gene enrichment P values were generated using a one-sided Poisson test. The most significant gene, SETD1A, has been previously identified as a schizophrenia risk gene¹³. LoF = loss-of-function. DNV = de novo variant.

Gene	New trios (n=613)		Published trios (n=2,831)		All trios (n=3,444)
	LoF DNVs	P	LoF DNVs	P	LoF DNVs	P
SETD1A	0	1	3	1.90E-06	3	3.00E-06
CUL1	2	3.60E-05	1	0.04	3	2.00E-05
TAF13	0	1	2	2.40E-05	2	3.30E-05
GALNT9	0	1	2	2.90E-05	2	4.20E-05
HENMT1	0	1	2	5.50E-05	2	7.90E-05
PAF1	1	0.0028	1	0.013	2	0.00013
SV2B	0	1	2	0.00016	2	0.00023
NRXN3	0	1	2	0.00022	2	0.0003
HIVEP3	0	1	2	0.00026	2	0.00035
RB1CC1	0	1	2	0.00046	2	0.00065
SMARCC2	0	1	2	0.0005	2	0.00068
MKI67	0	1	2	0.00085	2	0.0012
CHD8	0	1	2	0.0009	2	0.0013
TENM1	1	0.0077	1	0.046	2	0.0014
TRIO	0	1	2	0.0012	2	0.0016
SCN2A	1	0.012	1	0.057	2	0.0024
DNAH9	0	1	2	0.0018	2	0.0026
KMT2C	0	1	2	0.0086	2	0.012
KIAA1109	0	1	2	0.01	2	0.015
TTN	1	0.16	2	0.22	3	0.092