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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Xenotransplantation. 2019 Sep 23;27(1):e12552. doi: 10.1111/xen.12552

Table 2.

Results of delayed lung transplantation in recipients of IBBMTx

Baboon ID PBMC and
BM
hCD47
expression
of BM
donor		 Timing
of
lung
Tx		 Chimerism
at the
time of
lung Tx		 Reduction
of
anti-pig
nAb after
IBBMTx		 IFN gamma
ELSIPOT		 Graft
survival
(day)		 Lung
findings		 SLA
matching
between
BM and
Lung
donors		 hCD47
expression
on graft
lung ECs
15P17 hCD47+ 49 Yes Yes Pan pig unresponsiveness 13 Graft loss but partially aerated Syngeneic cell line Positive
2715 hCD47+ 33 Yes Yes Pan pig unresponsiveness 14 Graft loss but partially aerated
17214 Without hCD47 28 NO
Lost chimera on day 25		 Yes Pan pig unresponsiveness 1 Almost hemorrhagic /congestion Negative
14P3 hCD47+ 91 No
Lost chimera on day 70		 Yes Pan pig unresponsiveness 4 Almost hemorrhagic /congestion Not syngeneic cell line,
SLA mismatched
14P84 hCD47+ 69 No
Lost chimera on day 70		 Yes Pan pig unresponsiveness 2 Totally hemorrhagic
14P54 hCD47+ 96 No
Lost chimera on day 70		 Yes Unresponsive to BM donor but small response to Rev 26 hours Almost hemorrhagic /congestion

IBBMTx: intra-bone bone marrow transplantation, IFN: interferon, EC: endothelium, nAb: natural antibody