Table 2:

Top 10 HLOD Scores from the All Aggregated Cancers Analysis

CHR	POS	TYPE	rsID	CLOD	HLOD	ALPHA	FUNC	GENE
12	106751805	SNV	rs61943670	3.3	3.3	1.0	intron	POLR3B
20	31660489	SNV	rs11700200	3.2	3.2	1.0	intron	BPIFB3
20	31671599	SNV	rs13036385	3.1	3.1	1.0	nonsyn exon	BPIFB4
9	5233558	DEL	N/A	3.0	3.0	1.0	intron	INSL4
16	4923091	SNV	rs2251666	3.0	3.0	1.0	intron	UBN1
20	31671209	SNV	rs4339026	2.9	2.9	1.0	nonsyn exon	BPIFB4
3	10258762	SNV	rs2302860	2.8	2.8	1.0	intron	IRAK2
20	31678534	SNV	rs2070326	2.8	2.8	1.0	syn exon	BPIFB4
6	146207563	SNV	rs1062067	2.8	2.8	1.0	ncRNA	LOC100507557
3	10261294	SNV	rs3895947	2.8	2.8	1.0	intron	IRAK2

HLOD scores for Top Ten Variants in the All Aggregated Cancers (AAC) analysis. Headers are as follows: CHR = chromosome, POS = position of the variant in basepairs (hg 19), TYPE = Type of variant; either single nucleotide variant (SNV) or deletion (DEL), rsID = rsID of the variant (if applicable), CLOD = cumulative LOD score of the variant across all 28 families, HLOD = heterogeneity LOD score of the variant across all 28 families, ALPHA = Alpha value of variant used in HLOD score calculation, FUNC = functional description of the variant; nonsynonymous exonic (nonsyn exon), synonymous exonic (syn exon), noncoding RNA (ncRNA), or intronic (intron), GENE = gene location of the variant.