Figure 1.

Experimental design to determine the efficacy of bisphosphonates, alone or in combination with metformin. Chemical structures of the test agents Zometa, Fosamax, and Metformin (A). Diagrammatic representation of the experimental design (B). F344 male rats were randomized and administered AOM at a dose of 15 mg/Kg BW once a week for two weeks s.c. and were fed control or experimental diets. Colon tumors were evaluated after termination. AOM-treated rats developed colonic tumors in the distal part of the colon, while saline-treated rats had normal-looking colons (C).