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Bisphosphonates and metformin synergized to inhibit colonic AdCa multiplicity and incidence. Comparison of the colonic AdCa multiplicity and incidence between control and experimental groups. Bisphosphonates alone cause non-significant inhibition of the colonic AdCa multiplicity. Importantly, combination of bisphosphonates and metformin led to significant suppression of the colon AdCa multiplicity (A) and incidence (B).
