Figure 2:

A) Plasma glucose (mg/dL) following MMTT in hypoglycemia [+] vs hypoglycemia [−] groups. B) Insulin secretory rate (μU/mL per min) in response to MMTT. Early phase insulin secretion is blunted in hypoglycemia [+] vs hypoglycemia [−](p=0.03). C) Plasma glucose (mg/dL) following MMTT. Hypoglycemia [+] subjects have higher plasma glucose at 60 minutes (p=0.004). but declines in glucose through 120 to 180 minutes of testing unlike NGT subjects whose blood glucose values stabilize at 120 minutes. Accordingly, glucose AUC_{120–180 min} was lower in the hypoglycemia [+] group (p= 0.015). D) Insulin secretory rate (μU/mL per min) in response to MMTT. Significant blunting of early phase insulin secretion is demonstrated in both hypoglycemia [−] AGT (purple) and hypoglycemia [+] (green) groups. Black dashed lines represent the Insulin secretory rates (μU/mL per min) for the 2 NGT-hypoglycemia [+] subjects. These subjects demonstrate loss of early phase insulin secretion despite normal glucose tolerance. After adjusting for glucose AUC over this interval, hypoglycemia [+] tended to have higher late insulin secretion than hypoglycemia [−] AGT (p=0.1).

Markers indicate mean value at that time point while bars indicate standard error of the mean. Black dashed lines are absolute insulin secretory rate for each of the two NGT-hypoglycemia [+] subjects. Red dashed line represents plasma glucose of 180mg/dL and blue dashed line represents plasma glucose of 70mg/dL. * indicates p-value <0.05 for that group’s glucose value compared with the hypoglycemia [+] group.