Table 4. Treatment strategies at the time of extubation between patients with extubation success and failure.
| Parameters | Extubation success (n = 82) | Extubation failure (n = 43) | P |
|---|---|---|---|
| IMV (%) | |||
| Mode (A/C, %) | 70 (85.4) | 40 (93.0) | 0.211 |
| Frequency (bpm) | 14 ± 3 | 14 ± 3 | 0.747 |
| Tidal volume (ml) | 461 ± 74 | 449 ± 49 | 0.415 |
| Inspiratory pressure (cmH2O) | 16 ± 4 | 15 ± 3 | 0.669 |
| PEEP (cmH2O) | 7 ± 3 | 9 ± 4 | 0.021 |
| FiO2 (%) | 72 ± 22 | 80 ± 22 | 0.037 |
| Time to extubation (days) | 13.5 ± 13.8 | 14.4 ± 12.9 | 0.739 |
| Sequential withdrawal with NPPV (%) | 31 (37.8) | 0 (0) | 0.000 |
| Analgesics and sedatives | |||
| Midazolam (mg/d) | 48.98 ± 48.08 | 73.08 ± 55.17 | 0.013 |
| Propofol (mg/d) | 395.22 ± 425.31 | 442.19 ± 522.59 | 0.589 |
| Fentanyl (mg/d) | 0.75 ± 0.45 | 0.93 ± 0.48 | 0.043 |
| Vasopressors (%) | 51 (62.2) | 37 (86.0) | 0.006 |
| Muscle relaxants (%) | 10 (12.2) | 6 (14.0) | 0.780 |
| Antibiotics | |||
| Number of antibacterial agents | 4 ± 7 | 4 ± 3 | 0.580 |
| Number of antifungal agents | 1 ± 1 | 1 ± 1 | 0.410 |
| Number of antiviral agents | 0 ± 0 | 0 ± 0 | 0.711 |
| Venous corticosteroids (%) | 54 (65.9) | 31 (72.1) | 0.477 |
| Venous diuretics (%) | 72 (87.8) | 37 (86.0) | 0.780 |
| Insulin (%) | 35 (42.7) | 23 (53.5) | 0.250 |
| Blood products | |||
| Albumin (%) | 75 (91.5) | 38 (88.4) | 0.750 |
| RBC (%) | 23 (28.0) | 19 (44.2) | 0.040 |
| Platelet (%) | 9 (11.0) | 3 (7.0) | 0.543 |
| Plasma (%) | 18 (22.0) | 13 (30.2) | 0.308 |
| Cryoprecipitate (%) | 3 (3.7) | 0 (0) | 0.551 |
Abbreviations: A/C, assist/control; FiO2, fraction of inspired oxygen; IMV, invasive mechanical ventilation; NPPV, non-invasive positive pressure ventilation; PEEP, positive end-expiratory pressure; RBC, red blood cell.