Table 5. Univariate and multivariate logistic regression of risk factors for extubation failure in patients with severe pneumonia.
| Variables | Univariate logistic regression | Multivariate logistic regression | ||
|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | |
| APACHEII | 1.096 (1.010–1.188) | 0.027 | 1.141 (1.022–1.273) | 0.019 |
| LIS | 1.596 (0.947–2.688) | 0.079 | ||
| GOCA | 1.356 (1.025–1.794) | 0.033 | ||
| Respiratory rate (bpm) | 1.072 (1.014–1.134) | 0.015 | ||
| New-onset septic shock (%) | 2.878 (1.237–6.698) | 0.014 | ||
| Ejection fraction (%) | 0.963 (0.923–1.006) | 0.092 | 0.965 (0.925–1.007) | 0.097 |
| pH | 0.009 (0.000–0.910) | 0.045 | ||
| PaO2/FiO2 (mmHg) | 0.995 (0.990–1.000) | 0.056 | ||
| HCO3− (mmol/l) | 0.923 (0.849–1.003) | 0.059 | ||
| TB (μmol/l) | 1.035 (0.995–1.076) | 0.087 | ||
| Glucose (mmol/l) | 1.079 (0.992–1.172) | 0.076 | 1.122 (1.008–1.249) | 0.035 |
| APTT (s) | 1.020 (1.000–1.041) | 0.055 | ||
| Myoglobin (ng/ml) | 1.000 (1.000–1.001) | 0.078 | ||
| BNP (pg/ml) | 1.000 (1.000–1.000) | 0.044 | ||
| Complement 3 (g/l) | 0.146 (0.023–0.912) | 0.039 | ||
| PEEP (cmH2O) | 1.132 (1.016–1.263) | 0.025 | ||
| FiO2 (%) | 1.018 (1.001–1.036) | 0.039 | ||
| Sequential withdrawal with NPPV (%) | 0.000 (0.000–) | 0.998 | ||
| Midazolam (mg/d) | 1.009 (1.002–1.017) | 0.016 | ||
| Fentanyl (mg/d) | 2.304 (1.011–5.247) | 0.047 | 3.010 (1.100–8.237) | 0.032 |
| Vasopressors (%) | 3.748 (1.419–9.900) | 0.008 | ||
| RBC transfusion (%) | 2.031 (0.939–4.390) | 0.072 | 2.774 (1.062–7.252) | 0.037 |
Abbreviations: APACHE II, acute physiology, age, chronic health evaluation; APTT, activated partial thromboplastin time; BNP, brain natriuretic peptide; CI, confidence interval; FiO2, fraction of inspired oxygen; GOCA, gas exchange, organ failure, cause, associated disease; HCO3−, bicarbonate ion; LIS, lung injury score; NPPV, non-invasive positive pressure ventilation; OR, odds ratio; PaO2/FiO2, ratio of partial pressure of arterial oxygen to fraction of inspired oxygen; PEEP, positive end-expiratory pressure; RBC, red blood cell; TB, total bilirubin.