Table 4.
Multivariate Cox’s proportional hazard model regression analyses of candidate microRNAs affecting MACCE-free survival
| Items | Multivariate Cox’s regression | |
|---|---|---|
| P value | HR (95% CI) | |
| MiR-18a-5p (high vs. low) | 0.434 | 1.400 (0.603–3.250) |
| MiR-18b-5p (high vs. low) | 0.921 | 1.043 (0.454–2.398) |
| MiR-26b-5p (high vs. low) | 0.928 | 1.041 (0.437–2.481) |
| MiR-27a-3p (high vs. low) | 0.465 | 1.369 (0.590–3.174) |
| MiR-30e-5p (high vs. low) | 0.105 | 0.467 (0.186–1.172) |
| MiR-92a-3p (high vs. low) | 0.001 | 0.190 (0.069–0.524) |
| MiR-106a-5p (high vs. low) | 0.217 | 0.555 (0.218–1.412) |
| MiR-126-5p (high vs. low) | 0.009 | 0.278 (0.107–0.725) |
| MiR-134-5p (high vs. low) | 0.112 | 1.982 (0.852–4.612) |
| MiR-199a-3p (high vs. low) | 0.856 | 0.926 (0.402–2.134) |
| MiR-223-3p (high vs. low) | 0.255 | 0.617 (0.268–1.418) |
| MiR-423-5p (high vs. low) | 0.009 | 3.823 (1.408–10.382) |
| MiR-652-3p (high vs. low) | 0.042 | 0.412 (0.176–0.969) |
HR hazard ratio, CI confidence interval
P value < 0.05 was considered significant. MACCE: major adverse cardiac and cerebral event; all microRNAs were divided by median values as high and low expressions