Fig. 8.

Effects of LTB₄, a FLAP inhibitor (BAY-X1005) and a BLTR antagonist (LY255283) on infarction volume after tMCAO. (a) LTB₄ loading by intracarotid infusion over 30 min before tMCAO (60 min) increased infarct volume, n = 4 per group. ***p < 0.001 against the vehicle group by two-tailed independent t test. (b) Administration of BAY-X1005 (0.2 mg/kg, i.p.) and LY255238 (1 mg/kg, i.p.) 10 min prior to tMCAO (100 min) reduced infarct volume, n = 4 per group. *p < 0.05 against the vehicle group by one-way ANOVA followed by Tukey post hoc test. Representative thionin-stained sections for each treatment group are presented. Total number of animals used was 20