Fig. 4.

DHA diet influences inflammatory constraints in G93A mice. Anti-inflammatory indexes of fatty acid profiles from LSC of G93A mice are significantly enhanced by DHA supplementation, irrespective of age and gender (a). In line with this, plasmatic TNF-α concentration is also decreased in 90-day-old G93A male mice (b). Bars indicate mean values, whereas error bars represent ± S.E.M. In (a), significant differences between dietary groups (*p < 0.05, ***p < 0.001, ****p < 0.0001) were evaluated by a Bonferroni post hoc analysis after 2-way ANOVA, accounting age and diet. In (b), differences between dietary groups were evaluated by an ANOVA analysis followed by a Bonferroni post hoc analysis, being ***p < 0.001