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. 2019 Oct 15;17(1):340–355. doi: 10.1007/s13311-019-00784-7

Fig. 2.

Fig. 2

l-CDL attenuates vincristine-induced degeneration of the sciatic nerve and the prevalence of atypical mitochondria. (A) All six micrographs are shown at the same magnification (× 5000, bar = 2 μm). Normal myelinated (m) and unmyelinated fibers (n) were observed in the sham group. Severe degeneration of myelin and axons in large myelinated fibers was observed in the vincristine-treated group (day 14), whereas unmyelinated fibers appeared in looser bundles and were swollen. Shrinkage of the axons of myelinated fibers was observed on day 14 (p). l-CDL, particularly the high dose of l-CDL, and oxycodone reduced the degeneration of myelinated and unmyelinated fibers compared with the vincristine-treated group. n = 5 mice/group. (B–E) Representative ultrastructural images show the prevalence of atypical mitochondria in A-fibers (B) and C-fibers (C) in the six different groups (× 30,000, bar = 0.5 μm). The application of all three doses of l-CDL, especially the high dose of l-CDL, significantly decreased the prevalence of atypical mitochondria (indicated by arrows) compared with the vincristine-treated group. ###P < 0.001 compared with the sham control; **P < 0.01 and ***P < 0.001, compared with the vincristine-treated group, ANOVA followed by Tukey’s post hoc test, n = 5 mice/group. All data are presented as means±S.D.