Low cortical zinc in R6/1 mice. WT and R6/1 mice were aged in different cohorts to 8, 12, 16, and 20 weeks. Zinc levels were measured in (A) cortex, (B) hippocampus, (C) striatum, (D) midbrain, (E) cerebellum, and (F) liver. Data are mean ± S.E. N is indicated in column bars. All data were analyzed with two-factor ANOVA. *P < 0.05; **P < 0.01; ***P < 0.001