Fig. 2.

Zinc-deficient diet accelerates decline in R6/1 mice. WT and R6/1 mice were fed either a control or zinc-deficient diet from 6 weeks of age and their (A) weight, (B) motor performance on the rotarod, (C) clasping phenotype, and (D) cognitive performance on the Y-maze test were measured in the intervals recorded. n[WT control diet] = 16 (8 female); n[WT zinc-deficient diet] = 16 (8 female); n[R6/1 control diet] = 16 (8 female); n[R6/1 zinc-deficient diet] = 9 female). Data are mean ± S.E. *P < 0.05; **P < 0.01